Endometrial Receptivity Analysis (ERA)


What Is Endometrial Receptivity Analysis?

An in vitro fertilisation (IVF) routine aims to accurately time the readiness of the endometrium and the placement of the embryo. Unfortunately, this timing is not always accurate, impairing implantation. That’s where endometrial receptivity analysis (ERA) comes in. ERA is a pathbreaking technology that helps embryologists to scientifically determine endometrial preparedness at a nanoscopic level. By performing an embryo transfer during the optimal endometrial window, the chances of implantation rise.

Why Choose Endometrial Receptivity Analysis?

Endometrial receptivity analysis (ERA) is far ahead of other methods of endometrial assessment. Here’s how.

Scientific Approach

Endometrial readiness differs from woman to woman and predicting the ideal window for implantation can thus be challenging. ERA is a customised diagnostic tool that identifies a conducive window for implantation accurately.

Obsolescence of Other Diagnostic Methods

Other diagnostic systems to assess endometrial viability hinge on structural variations in tissues and their results display tremendous variance. ERA detects even slight molecular discrepancies, ensuring that every tiny detail is accounted for.

Is Endometrial Receptivity Analysis Right for Me?

On Cloudnine, we recommend endometrial receptivity analysis (ERA) for guests who have a history of unsuccessful embryo implantation. Often, despite a spate of agreeable parameters like quality embryos, a healthy uterus and an adequate endometrial thickness, implantation fails to occur due to an ill-timed embryo transfer. ERA is also advisable for guests whose endometrial thickness fluctuates from cycle to cycle, not always touching the 8-millimetre benchmark.

What Are the Steps of Endometrial Receptivity Analysis?

An endometrial receptivity analysis (ERA) involves two main steps, which work in sync to provide insights to your fertility consultant about the health of your endometrium.


Endometrial Biopsy

First, an endometrial biopsy is performed by your doctor, between the 19th and 21st day of your menstrual cycle. The routine is conducted using a Pipelle catheter, and is quick and straightforward.


Gene Sequencing

Once the biopsy is performed, your doctor will carefully examine the pattern of the 236 genes that play a role in endometrial readiness. A pioneering technology hosted exclusively on Cloudnine then sieves through the data to recognise whether the endometrium is receptive or not. Based on the output, your fertility consultant will discuss a treatment route with you.

What Are the Risks of Endometrial Receptivity Analysis?

The risks associated with endometrial receptivity analysis (ERA) are few and far between. Risks, if any, could be environmental, or posed by the procedures related to ERA.


Any invasive procedure can give root to an infection, if not performed salubriously. Hygiene is one of our foremost priorities on Cloudnine with our sanitisation norms having set new trends in the Indian medical space. Our hospitals and equipment are thoroughly disinfected after every procedure.