DNA Fragmentation Index Of Sperm (DFI)


What Is DNA Fragmentation Index of Sperm (DFI)?

The quality and integrity of your sperm are vital factors in determining its motility, concentration and morphology. However, DNA fragmentation can damage sperm, and can be a contributor of subfertility and infertility. DNA fragmentation index (DFI) is a superior diagnostic and prognostic tool used to evaluate the degree of fragmentation of sperm. The procedure offers far better results than traditional tests, detecting details that reach beyond conventional methods.

Why Choose to Calculate DNA Fragmentation Index of Sperm?

DNA fragmentation index (DFI) is something that should be considered if infertility or subfertility of the male partner is suspected.

Early Diagnosis

Sperm DNA fragmentation provides a clear picture of the viability of sperm based on the integrity of its DNA. An early diagnosis can prevent unwanted stress and worry, with your fertility consultant personalising a treatment plan for you.

Unfavourable Outcomes of Fragmented Sperm

By opting to seek a diagnosis, and subsequently, a treatment plan, you can save yourself from unfavourable outcomes usually associated with fragmented sperm. Sperm fragmentation has been found to lead to miscarriages and chromosomal abnormalities in offspring, amongst other risks.

Is Calculating DNA Fragmentation Index of Sperm Right for Me?

With a rise of reproductive toxicants lurking in various environmental quarters, sperm fragmentation is on an incline. Sperm DNA fragmentation could be a barrier to male fertility. The possibility of fragmented sperm exists even when other attributes like sperm motility, count and morphology are normal. If you and your partner are experiencing difficulty conceiving, consider consulting a fertility specialist to explore the DNA fragmentation index of your sperm (DFI).

What Are the Steps of Calculating DNA Fragmentation Index of Sperm?

The DNA fragmentation index of sperm (DFI) is gauged through a straightforward test, akin to a regular semen evaluation.


Semen Procurement

At the outset, a semen sample is obtained from the male partner for examination.


Sperm Evaluation

Our specialised team of embryologists evaluates the semen sample by running it through an array of sophisticated diagnostic tests to measure the degree of sperm DNA fragmentation. The condition can be sidestepped with an effective fertility plan. Our fertility specialists will sit down with you and your partner to discuss a suitable solution, should you be diagnosed with sperm DNA fragmentation.

What Are the Risks of Calculating DNA Fragmentation Index of Sperm?

The risks that stem from sperm DNA fragmentation have no bearing on the health of the male partner. There are, however, some perceived limitations of the procedure.

Distinction of DNA

It is understood that only a subset of DNA plays a role in the functioning of the human body. Thus, while an evaluation may indicate fragmentation in certain areas of DNA, these functions may not be relevant at all. However, distinguishing between useful and redundant DNA may prove futile in the fragmentation testing process.

Threshold of DNA Fragmentation

There is no recognised threshold associated with sperm fragmentation. While it is well understood that fertile men demonstrate lower fragmentation levels than subfertile and infertile men, there is still an intersection that is being researched.